Description

The price is per package (25 bottles of 10 IU)

SALE OF GROWTH HORMONE EXCLUSIVELY ON ADVANCE PAYMENT!

COMPOSITION

Active Ingredient: Somatropin 4IU (1.33mg) / 10IU (3.33mg)

16 IU (5.33 mg) / 20 IU (6.67 mg)

Excipients: mannitol, glycine, sodium dihydrogen phosphate, sodium chloride.

Solvent: water for injection.

INDICATIONS

Growth retardation in children due to insufficient secretion of growth hormone, with gonadal dysgenesis (Shereshevsky-Turner syndrome), with chronic renal failure in the prepubertal period.

In adults with confirmed congenital or acquired growth hormone deficiency as replacement therapy.

METHOD OF APPLICATION AND DOSES

DINATROP is administered subcutaneously, slowly, 1 time per day, usually at night. Injection sites should be changed to prevent the development of lipoatrophy.

It is recommended to dissolve the contents of the vial in 1 ml of the supplied solvent, based on the calculated dose. To do this, the solvent is taken with a syringe and injected into the vial with the drug through the stopper. Gently shake until the contents of the vial are completely dissolved. Sharp shaking is unacceptable. The prepared solution is stored in a vial for no more than two weeks at a temperature of 2 C to 8 C.

Doses are selected individually, taking into account the severity of growth hormone deficiency, weight or body surface area, and effectiveness in the course of therapy.

In children with insufficient secretion of growth hormone, a dose of 25-35 mcg / kg / day (0.07-0.1 IU / kg / day) is recommended, which corresponds to 0.7-1 mg / m2 / day (2-3 IU / day). m2/day).Treatment begins as early as possible and continues until puberty and/or closure of bone growth zones. It is possible to stop treatment when the desired result is achieved.

With Shereshevsky Turner syndrome, with chronic renal failure in children, accompanied by growth retardation, a dose of 50 mcg / kg / day (0.14 IU / kg / day) is recommended, which corresponds to 1.4 mg / m2 / day (4.3 IU / day). m2/day). With insufficient growth dynamics, dose adjustment may be required.

With growth hormone deficiency in adults, the initial dose is 0.15-0.3 mg / day (corresponding to 0.45-0.9 IU / day) with its subsequent increase, depending on the effect. When titrating the dose, the level of insulin-like growth factor I (IGF-I) in the blood serum can be used as a control indicator. The maintenance dose is selected individually, but usually does not exceed 1 mg / day, which corresponds to 3 IU / day. Lower doses are recommended for the elderly.

PHARMACEUTICAL FORM

Lyophilizate for preparation of solution for subcutaneous administration 4 IU, 10 IU.

Lyophilisate: 4 or 10 IU in a glass vial.
Solvent: 1 ml in a neutral glass ampoule.
25 vials with lyophilisate together with 25 ampoules with solvent in a cardboard box with instructions.

STORAGE

Store in a place protected from light at a temperature of 2 C to 8 C.

Do not freeze.
Store the prepared solution at a temperature of 2°C to 8°C for 2 weeks.
Keep out of the reach of children.